The active site cavity is located on the surface of the protease and can bind substrate residues in positions P1' through P5 in the substrate binding subsites ...
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Diagram showing the active site residues of the main protease (Mpro) of SARS-CoV-2. The area and volume of the binding site are 335.94 Å 2 and 364.1 Å 3 ...
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Jun 24, 2020 · The SARS-CoV-2 3CL main protease (3CL Mpro) is a chymotrypsin-like protease that facilitates the production of non-structural proteins, which ...
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The 3CL protease of SARS-CoV-2 is 96% identical to the 3CLP protease from SARS-CoV indicating the conserved nature of the protein structure. Inhibiting the 3CL ...
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b Crystal structure of SARS-CoV-2 Mpro with a substrate peptide (nsp9-nsp10) bound at the active site of both monomers (light and darker gray). The peptide is ...
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The height of a letter at each position reflects its probability in the alignment; each of the logos shown represents the consensus of 11 M pro cleavage sites ...
Oct 23, 2020 · Telaprevir and narlaprevir possess substituents in six positions, including chemical groups at P1′ and P1 through P5, whereas boceprevir lacks a ...
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Jun 20, 2022 · The fitness landscapes revealed a non-active site location on the surface that is extremely sensitive to mutation, making it a favorable ...
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