(A) Schematic structure of an sRNA with a 5'-terminal seed region and a 3'-terminal terminator stem-loop structure. sRNAs compete rapidly for Hfq binding (blue ...
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What is the binding site of HFQ?
Gene regulation by sRNA and Hfq in bacteria. Hfq can protect sRNAs from ribonuclease cleavage (A) or recruit RNases to degrade of sRNA-mRNA complexes (B).
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The Hfq-binding site is essential for Hfq to facilitate the pairing between a given sRNA and the target mRNA. While the functional role of the Hfq-binding site ...
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Secondary structure in the mRNA leader (gray) masks the ribosome-binding site and prevents initiation of translation. Expression of a complementary sRNA (blue) ...
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Recent discoveries have revealed that the expression of many genes is controlled by a plethora of base-pairing noncoding small regulatory RNAs (sRNAs), ...
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Nov 17, 2014 · The Sm-like protein Hfq (host factor Q-beta phage) facilitates regulation by bacterial small noncoding RNAs (sRNAs) in response to stress and ...
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In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences.
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