May 30, 2022 · In this work, we illuminate how the dynamic supramolecular framework of squalene-hopene cyclases (SHCs) can be tailored to break with this ...

Tailoring the squalene-hopene cyclase for stereoconvergent and efficient cationic cyclization cascades. Andreas Schneider1†, Christian Curado2†, Thomas B ...

They are biochemically synthesized from linear precursors (squalene, 2,3-oxidosqualene) in only one enzymatic step that is catalyzed by squalene-hopene cyclase ...

Two farnesyl diphosphate units can be tail-to-tail condensed to squalene and then cyclized to hopene by the key enzyme of hopanoid biosynthesis, squalene-hopene ...

Squalene–hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the ...

A squalene hopene cyclase enzyme was first discovered and later engineered to catalyse the cyclization of Homofarnesol to Ambrox, which is widely used as a ...