Use missiles and super missiles primarily, but the Ice Beam works as well. Let's go over the attacks so you know what to avoid. If the Omega Metroid starts banging its tail on the ground, rocks will start falling from the ceiling. Instead of moving out of the way, shoot them down to get health and ammo.

It was originally an Infant Metroid from the Restricted Laboratory, developed from the cells of the Baby. It escaped during the laboratory's destruction, and went to feed on numerous X Parasites, rapidly molting through its life cycle until reaching the Omega stage as it made its way to the Docking Bays.

Conceived by scenario designer Makoto Kano and designed by Hiroji Kiyotake, series co-creator Yoshio Sakamoto conceived of the idea of making Samus a woman midway through the first Metroid's development, which the development team voted in favor of.

Your best strategy against the Omega Metroid is to attack it as the SA-X did: fire charged Ice Beam shots directly into its belly.