Sep 27, 2023 · 001976 NOD/ShiLtJ The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is ...
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001976 NOD/ShiLtJ The NOD/ShiLtJ strain (commonly called NOD) is a polygenic model for autoimmune type 1 diabetes. Diabetes in NOD mice is characterized by ...
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Description: Mus musculus with name NOD/ShiLtJ from IMSR. Species: Mus musculus. Synonyms: Non-obese Diabetic. NOD/LtJ. Notes: gene symbol note: hemolytic ...
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People also ask
Why do NOD mice develop diabetes?
NOD mice have a mutation in exon 2 of the CTLA-4 gene, which causes it to be spliced incorrectly. CTLA-4 plays a major role in suppressing the T-cell immune response. Without the proper functioning of CTLA-4, T-cells attack the insulin producing cells. This results in Type 1 Diabetes.
What is the BKS mouse strain?
BKS db/db Mice (JAX® Mice Strain) Details
db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and come to be hypoinsulinemic.
What is the incidence of diabetes in the NOD?
For one, NOD mice have a high incidence of autoimmune diabetes, especially in females where it reaches 70 to 90% by 30 weeks (25).
What is the history of the NOD mouse?
NOD inbred mice originated early on in the inbreeding of the Cataract Shionogi (CTS) strain. These mice were originally outbred Jcl:ICR mice. At F6, the progenitors of the future NOD/Shi mice were inbred on the basis of an elevated fasting blood glucose level in cataract-free mice.
Sep 27, 2023
Dec 19, 2014 · This inbred strain, first reported in 1980, was developed in Japan by selective breeding of outbred ICR:Jcl mice at the Shionogi Research ...
Control strain for B6N mice, including mice from the. Knockout Mouse Project (KOMP). • Protected from genetic drift by the exclusive. JAX® Genetic Stability ...
This review compares two novel polygenic mouse models of type 2 diabetes (T2D), TALLYHO/JngJ and NONcNZO10/LtJ, and contrasts both with the well-known ...
Apr 29, 2022 · ... strain represents the only mouse model that spontaneously develops autoimmune diabetes (2–4). The NOD strain is originally derived from ...
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