TAZVERIK ® is indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. This indication is approved under accelerated approval based on overall response rate and duration of response.
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Dec 8, 2020 · Tazemetostat is an oral, SAM-competitive inhibitor of EZH2, whose blockade prevents the methylation of histone H3K27, thus decreasing the growth ...
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Jan 24, 2020 · Tazverik is only the second targeted therapy approved for a soft tissue sarcoma and the first treatment option specifically for epithelioid ...
Jan 12, 2021 · Epithelioid sarcoma (ES) is a rare soft tissue sarcoma found in 0.05 people per 100,000 in the USA. It can recur multiple times in the lymph ...
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On January 23, 2020, the Food and Drug Administration granted accelerated approval to tazemetostat (TAZVERIK, Epizyme, Inc.) for adults and pediatric ...
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Background: ES is a rare soft tissue sarcoma that metastasizes in approximately 30% to 50% of cases. More than 90% of ES tumors lack expression of INI1, ...
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Dec 8, 2020 · Tazemetostat is a new oral compound able to inhibit EZH2, therefore neutralizing this effect. Tazemetostat has been investigated in a Phase II ...
Sep 9, 2021 · Tazverik is the first approved treatment for metastatic/locally advanced epithelioid sarcoma in patients aged 16 years and older.
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Jan 23, 2020 · Tazverik's approval was based on the results of a clinical trial enrolling 62 patients with metastatic or locally advanced epithelioid sarcoma.
Tazemetostat has been approved for the treatment of patients aged 16 years and older with metastatic or advanced ES not eligible for complete resection, based ...