Similar to the human condition, NOD mice develop autoantibodies (1) and exhibit increases in circulating autoreactive T cells (2, 3) prior to the onset of T1D. The β cell antigens that are targeted are also similar between these species (4).
Feb 23, 2018
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Apr 29, 2022 · As in PWT1D, NOD mice can develop spontaneous autoimmune thyroiditis (SAT). In NOD mice, the cumulative incidence at one year ranges from ~5% to ...
Autoantibodies are commonly found in healthy individuals and strains of mice that are not prone to autoimmunity. The present study was undertaken to.
Dec 1, 2002 · The nonobese diabetic (NOD)3 mouse is a useful model to examine the immunoregulatory abnormalities that lead to autoimmune β cell destruction ...
May 15, 2017 · In the NOD mouse, only insulin autoantibodies have been documented reliably, despite findings of insulin, GAD, and IA-2 as target autoantigens ( ...
Thyroid lesions and anti-MTg autoantibodies did not develop in CBA/J (H-2k) or NOD.SWR(H-2q) mice after administration of NaI water. Both CD4+and CD8+T ...
Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. ... Diabetes develops in NOD mice as a result of insulitis ...
Sep 3, 2020 · Tang Q, Henriksen KJ, Bi M, FInger EB, Szot G, Ye J, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
Jan 11, 2018 · In our study, we have shown that the AID deficiency accelerated and increased autoimmune diabetes in the NOD mouse. In the absence of AID, NOD ...
Apr 26, 2023 · In the present study, we investigated the ability of this relatively safe transplant modality to eliminate autoimmune T-cell clones in the NOD ...