Thrombomodulin as a Physiological Modulator of Intravascular Injury
www.ncbi.nlm.nih.gov › PMC7525002
Sep 16, 2020 · Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin. Am J Physiol ...
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Jul 20, 2007 · Thrombin activatable fibrinolysis inhibitor (TAFI), when activated, forms a basic carboxypeptidase that can inhibit fibrinolysis.
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Jan 4, 2024 · Upon interaction with thrombin, the cytoplasmic domain of thrombomodulin recruited both β-arrestin-1 and -2 to the plasma membrane. Thus, the ...
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1 Thrombomodulin. Thrombomodulin is an endothelial cell thrombin receptor that converts thrombin into an anticoagulant capable of activating protein C ...
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Clone 1 enhances fibrinolysis in human whole blood under flow. 1. INTRODUCTION. To prevent excessive fibrin accumulation, thrombin formation is controlled by ...
Thrombin, a coagulation protease, is primarily known for its regulation of hemostasis and thrombosis. However, this enzyme also plays important roles in ...
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Jun 17, 2020 · Key Points. We herein report the first case of functional TM deficiency resulting from a mutation in the thrombin-binding domain of the TM ...
Aug 15, 2019 · Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective ...
Jan 11, 2018 · Abstract. Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is ...
Two separate regions of thrombin are required for this reaction: exosite I for thrombomodulin binding, and the active site for protein C activation (Table 1).