Three states for the Hedgehog pathway, for Cubitus interruptus, and for Hedgehog target genes. In the nucleus, the repressor form of Cubitus interruptus ...
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The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Drosophila Hh target genes and thus represents the most downstream ...
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We interpret this as evidence against the existence of Ci-independent branches in the Hh signal transduction pathway and propose that most cases of apparent Ci/ ...
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We show that Ci is a sequence-specific DNA binding protein that drives transcription from the wg promoter in transiently transfected cells. We demonstrate that ...
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In Drosophila, Hedgehog signaling regulates transcription of target genes by modifying the activity of the DNA-binding protein Cubitus interruptus (Ci).
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In flies, Hh alters the interactions among a set of core signaling components to elicit the transcriptional induction and de-repression of Hh target genes ...
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