The thrombin-thrombomodulin complex inhibits fibrinolysis by activating the procarboxypeptidase thrombin-activatable fibrinolysis inhibitor. Here we present the 2.3 A crystal structure of human alpha-thrombin bound to the smallest thrombomodulin fragment required for full protein-C co-factor activity, TME456.
People also ask
What does thrombin activate?
What protein is activated by thrombin?
How is thrombomodulin activated?
What is the function of the thrombin enzyme?
Rating
(1)
Warfarin and heparin are anticoagulant drugs that act against clotting factors. thrombin-thrombomodulin complex is necessary for activation of: a. protein C
ABSTRACT. Protein C activation on the surface of the endothelium is critical to the negative regulation of blood coagulation.
Missing: necessary | Show results with:necessary
Thrombin acts as procoagulant not only by cleaving fibrinogen to fibrin but also by interacting with protease-activated receptors to activate various ...
People also search for
Via its anion-binding exosite I, thrombin binds to EGF5 through EGF6, whereas EGF4 through EGF6 is required for activation of PC. In contrast, activation of ...
Thrombomodulin thereby functions as a cofactor in the activation of protein C by thrombin, approximating the 2 proteins (Figure 4A) and enabling allosteric ...
Once prothrombin is activated, thrombin can escape the activation complex and is then free to attack its target substrates. Thrombin is unique amongst the ...
Jul 6, 2020 · Importantly, the thrombin-thrombomodulin complex has exclusive activity toward protein C and no appreciable activity toward fibrinogen and PAR1 ...
For anticoagulant and protein C activation, thrombomodulin is the most important cofactor because protein C is unlikely to be activated by free thrombin. Thus, ...
Missing: necessary | Show results with:necessary
Residues of thrombin important for TAFI, but not protein C, activation are located above the active site cleft, constituting E25, D51, and R89/R93/E94, whereas ...
Related searches