The structure shows that E2F binds at the interface of the A and B domains of the pocket making extensive interactions with conserved residues from both. We ...

2b, it can be seen that the Fe 3+ and O 2À ions are arranged alternatively parallel to the Fig. 1 (a-c) c plane, which is thus terminated with either positively ...

The coordination sphere of the Fe III atom is that of a slightly distorted octahedron. The crystal under investigation was a two-component pseudo-merohedral ...

The retinoblastoma protein (Rb) regulates cell proliferation through its association with E2F transcription factors and other proteins. The Rb “pocket” ...

The retinoblastoma tumor suppressor protein (pRb) regulates the cell cycle, facilitates differentiation, and restrains apoptosis.

Jul 14, 2016 · Structural and functional analysis provides insight into oncogenicity of mutations in RbN and identifies a unique phosphorylation-regulated site ...

The crystal structure of the Rb N-terminal domain (RbN), reveals a globular entity formed by two rigidly connected cyclin-like folds. The similarity of RbN to ...

We describe here the 1.8 angstrom crystal structure of the universal core of the SRP, revealing protein recognition of a distorted RNA minor groove. Nucleotide ...