Thrombomodulin is an anticoagulant protein cofactor that modulates the substrate specificity of thrombin and promotes the cleavage of protein C. The structure-function relationships of the thrombin-thrombomodulin interaction have been explored by recombinant DNA and protein chemistry methods.
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Thrombomodulin is a cell surface-expressed glycoprotein that serves as a cofactor for thrombin-mediated activation of protein C (PC), an event further ...
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Endothelial membrane-bound TM forms a high-affinity complex with thrombin (Kd ∼0.5 nmol L−1), and inhibits thrombin interaction with fibrinogen and protease- ...
First and foremost, APC is a natural anticoagulant in that it suppresses further thrombin formation by proteolytically destroying coagulation factors Va and ...
Jan 22, 2024 · Thrombomodulin (TM) is a type 1 receptor best known for its function as an anticoagulant cofactor for thrombin activation of protein C on ...
A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to thrombin, ...
Because the benefit of Solulin is focused on its stability as an anticoagulant, the binding ability to the interfering protein is disrupted. The N‐terminal of ...
TM is a vasculoprotective integral membrane glycoprotein displaying anticoagulant, antifibrinolytic, and anti-inflammatory properties and, as such, is a pivotal ...
Anticoagulant treatment with coumarin derivates and warfarin is widely used in the prevention of thromboembolic events of both the venous and the arterial sides ...
To prevent unnecessary clotting, the endothelium expresses anti-coagulant factors, such as tissue factor pathway inhibitor and thrombomodulin (TM), and ...