Jan 7, 2015 · The thrombomodulin (TM)/activated protein C (APC) system plays an important role in maintaining the homeostasis of thrombosis and hemostasis ...
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Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a critical cofactor for thrombin- ...
Here we identify the thrombomodulin (Thbd)–activated protein C (aPC) pathway as a novel mechanism for mitigation of total body irradiation (TBI)-induced ...
Jul 6, 2020 · Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease ...
Rational Design of Protein C Activators | Scientific Reports - Nature
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Mar 15, 2017 · Here, we present a fusion protein where thrombin and the EGF456 domain of thrombomodulin are connected through a peptide linker. The fusion ...
Nov 5, 2018 · Patients with PF develop a severe deficiency in protein C (PC), a serine protease that is a key endogenous anticoagulant. ... PC is activated at ...
Feb 10, 2005 · The interaction of thrombin (IIa) with thrombomodulin (TM) is essential for the efficient activation of protein C (PC).
Human protein C is a vitamin K-dependent glycoprotein structurally similar to other vitamin K-dependent proteins affecting blood clotting, such as · Inactive ...
Activated protein C (aPC) is a natural anticoagulant due to its actions that proteolytically inactivate clotting factors Va and VIIIa. aPC is generated after an ...
Thus, the activation of protein C is efficiently catalyzed on the endothelial cell surface by thrombin (T) bound to thrombomodulin (TM). TM functions as a ...