One to two percent of children born with this syndrome have a life expectancy of two to three years; however, most individuals reach adulthood and can live a life span into the fifties. Early treatment should be considered for the most severe issues with this condition to prolong life expectancy.

The prevalence of 22q11. 2DS has been estimated to be approximately 1/3000 to 1/6,000 live births. These numbers may well be higher due to the variability of the condition, difficulty in properly diagnosing, and lack of newborn screening.

Developmental delay is often seen in children with 22q11. 2 deletion syndrome, including a delay in language. As the child grows older, intellectual disability and learning differences are likely to become more obvious. Verbal IQ is often greater than performance IQ as the child grows.

22q11. 2 deletion is almost as common as Trisomy 21, also known as Down syndrome, which is a more widely recognized chromosomal disorder. Children with 22q11.